Care plan

Ion Channels and G Proteins

Discussion on  Ion Channels and G Proteins

NUR 514 Clinical Soap note 3

Submission Instructions:

  • Your SOAP note should be clear and concise and students will lose points for improper grammar, punctuation, and misspellings.
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4k35 safety n quality

PATHO WEEK 7

ROLES WEEK 7

Question 8

Please complete this assignment: elaborate on each part, especially the differential diagnoses. Use a current clinical guideline for the treatment plan. 

Discussion NT W7 Reply to Peer 1

Transition of the concept model to transition involves several steps, these steps will help identify if the idea is a unique one or it has previous being suggested and or explore. Such steps are concept design, literature search and research questions and lastly how unique research are. Gap filling should also be included to finish the research. Liehr and Smith’s 10-phase iterative critical thought process for concept building intertwines theoretical and empirical dimensions. The process evolves through abduction, induction, and deduction (Liehr & Smith, 2018). It begins by naming a phenomenon of interest (nurturing resilience) based on fragmented observations, then combines these observations into a generalizable coherent whole. Although the general perspective is then deduced to specifics, the process repeats as necessary until defining properties of the emerging concept are identified; these properties emerge through analysis of both literature and empirical evidence. A coherent synthesis of all dimensions of knowing is then crafted into a cohesive presentation of the built concept (Liehr & Smith, 2018).

Conceptual models can provide a visual representation of specific research questions. They also can show key components of programs, practices, and policies designed to promote health. Conceptual models may provide improved guidance for prevention and intervention efforts if they are based on frameworks that integrate social ecological and biological influences on health and incorporate health equity and social justice principles (Brady et al, 2020). To transition to a concept model followed by a framework, a research proposal is a critical step in the research process, ideas must be unique and have a purpose. Refining the concept is the first step needed to proceed with the research, structure and research must be present. Making connection between the concept model and the research proposal and testing the theory must also be present to validate and continue the research, the model should be tested or explored through the proposed research design and methods and lastly revisions and reviews must be made and analyzed. Researchers, practitioners, and policy makers can use conceptual models to convey ideas to diverse audiences (Brady et al, 2020). The principles of the thematic analysis technique, such as coding of data, searching for themes, refining the themes, and reporting the findings, are relatable to other qualitative methods, such as discourse analysis Thematic analysis is a method to analyze qualitative data (Flick, 2022). In conclusion, to create a research concept model for a specific research study a theoretical foundation must be present. Meticulous research and supporting evidence that supports ethical and logical considerations is a must. The careful reading of chapter 21 in the book called Middle Range Theory for Nursing written by Mary Jane Smith provides the reader with all the tools to successfully embark on a specific concept model that will transition to research proposal.

References

Naeem, M., Ozuem, W., Howell, K., & Ranfagni, S. (2023). A Step-by-Step Process of Thematic Analysis to Develop a Conceptual Model in Qualitative Research. International Journal of Qualitative Methods, 22. https://doi.org/10.1177/16094069231205789

Smith, M. J., Liehr, P. R., & Carpenter, R. (2024). Middle range theory for nursing. Springer Publishing.

Brady, S. S., Brubaker, L., Fok, C. S., Gahagan, S., Lewis, C. E., Lewis, J., Lowder, J. L., Nodora, J., Stapleton, A., Palmer, M. H., & Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium (2020). Development of Conceptual Models to Guide Public Health Research, Practice, and Policy: Synthesizing Traditional and Contemporary Paradigms. Health promotion practice, 21(4), 510–524. https://doi.org/10.1177/152483991989086

Flick U. (2022). The Sage handbook of qualitative research design. Sage.

Discussion NT W7 Reply to Peer 2

The Transition of Conceptual Models to Research Proposals

      Conceptual models serve as the foundational framework that guides research proposals by providing structure, clarity, and direction for inquiry. In nursing research, conceptual models help define key variables, establish relationships between concepts, and justify the significance of a study. Chapter 21 explores the role of conceptual models in research, emphasizing their transition from abstract frameworks to structured proposals that drive evidence-based practice. A conceptual model provides a lens through which a researcher views a phenomenon, offering a theoretical foundation that informs research questions, hypotheses, and study design. For instance, a model like Meleis’ Transitions Theory can guide studies on patient adaptation to chronic illness by outlining key transition points and influencing factors (Meleis, 2010). Once a model is chosen, researchers align it with their problem statement, ensuring that study variables and interventions reflect the theoretical underpinnings. This alignment is crucial in shaping the research methodology, as it dictates the selection of qualitative or quantitative approaches and determines measurement tools that accurately capture the concepts under study (Polit & Beck, 2021).

      Furthermore, conceptual models facilitate the interpretation of findings by providing a structured explanation of observed relationships. The use of models enhances the rigor of research by ensuring consistency in data collection and analysis, ultimately leading to more meaningful conclusions that contribute to nursing knowledge. For example, Orem’s Self-Care Deficit Nursing Theory has been widely applied to research on patient self-management, influencing nursing interventions that promote autonomy and improved health outcomes (Taylor, Renpenning, & Geden, 2022). In summary, transitioning from a conceptual model to a research proposal involves integrating theoretical perspectives with methodological rigor. This process strengthens the study’s foundation, ensuring that research remains systematic, relevant, and impactful in advancing nursing practice.

References

Meleis, A. I. (2010). Transitions theory: Middle range and situation-specific theories in nursing research and practice. Springer Publishing Company.

Polit, D. F., & Beck, C. T. (2021). Nursing research: Generating and assessing evidence for nursing practice (11th ed.). Wolters Kluwer.

Taylor, S. G., Renpenning, K., & Geden, E. (2022). Self-care theory in nursing: Selected works of Orem’s self-care deficit nursing theory. Springer.

Discussion P W7 Reply to Peer 1-1

 Gastric Acid Secretion and Its Regulation

      Gastric acid secretion is regulated by a complex interplay of neural, hormonal, and paracrine pathways. The primary stimuli include acetylcholine (ACh), gastrin, and histamine. Acetylcholine, released by the vagus nerve, directly stimulates parietal cells to secrete hydrochloric acid (HCl). Gastrin, produced by G cells in the antrum of the stomach, binds to CCK2 receptors on parietal cells and enterochromaffin-like (ECL) cells, prompting histamine release. Histamine, secreted by ECL cells, activates H2 receptors on parietal cells, enhancing acid production via the cyclic AMP pathway (Niv & Dickman, 2020). While gastric acidity is crucial for digestion and microbial defense, excessive acidity poses significant risks. Strong acidity can lead to mucosal injury, increasing the likelihood of gastritis, peptic ulcer disease (PUD), and gastroesophageal reflux disease (GERD). Chronic acid exposure can also contribute to Barrett’s esophagus, a precancerous condition. Furthermore, excessive acid can impair pancreatic enzyme function and nutrient absorption, exacerbating deficiencies in iron, calcium, and vitamin B12 (Feldman et al., 2022).

Pathophysiology of Helicobacter pylori

      Helicobacter pylori (H. pylori) is a Gram-negative, spiral-shaped bacterium that colonizes the gastric mucosa, primarily in the antral region. It produces urease, an enzyme that hydrolyzes urea into ammonia and carbon dioxide, creating a local buffering environment that allows the bacteria to survive in the highly acidic stomach. Additionally, H. pylori adheres to gastric epithelial cells and induces an inflammatory response by releasing virulence factors such as cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), leading to mucosal damage (Malfertheiner et al., 2021). The persistent inflammation can disrupt normal gastric physiology, increasing acid secretion in duodenal ulcers or leading to gastric atrophy and hypochlorhydria in chronic gastritis, increasing the risk for gastric cancer.

References

Feldman, M., Friedman, L. S., & Brandt, L. J. (2022). Sleisenger and Fordtran’s Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. Elsevier.

Malfertheiner, P., Megraud, F., Rokkas, T., Gisbert, J. P., Liou, J. M., Schulz, C., & Wauters, T. (2021). Management of Helicobacter pylori infection: The Maastricht VI/Florence consensus report. Gut, 70(12), 2114-2132.

Niv, Y., & Dickman, R. (2020). Gastric acid secretion and its clinical implications: The role of histamine and gastrin. World Journal of Gastroenterology, 26(45), 7287-7301.